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This paper describes a general method for manipulation of nuclear spins in zero magnetic field. In the absence of magnetic fields, the spins lose the individual information on chemical shifts and inequivalent spins can only be distinguished by nuclear gyromagnetic ratios and spin-spin couplings. For spin-1/2 nuclei with different gyromagnetic ratios (i.e., different species) in zero magnetic field, we describe the scheme to realize a set of universal quantum logic gates, e.g., arbitrary singlequbit gates and two-qubit controlled-NOT gate. This method allows for universal quantum control in systems which might provide promising applications in materials science, chemistry, biology, quantum information processing and fundamental physics.

Hypoxia-activated prodrug is an appealing oncotherapy strategy, but limited by insufficient tumor hypoxia. Moreover, standalone prodrug fails to treat tumor satisfactorily due to tumor complexity. Herein, a nanosystem (TPZ@FeMSN-GOX) was...