The appearance of Islam in Mali dates from the thirteenth century (period of the empire of Mali). The main actors of this Islamization were the traders and the Almoravids. From this time to now Islam remains popular as well as its leaders. Religious leaders are the interface between public administration and society. Mali opted for democracy in 1991, which created more political openness, particularly in terms of public freedoms. Therefore, we are witnessing the rise of Muslim influence in the democratic game. This fact provokes the debate on the place of Islam in political life. The distinction between politics and religion is necessary, but it does not absolutely forbid Muslim actors from taking a democratic stand on issues relating to the life of the nation. The religious space is characterized by the multiplication of sects and the competition between its actors. This phenomenon is reinforced by the support of the powers of the Muslim world which are in logic of ideological competition. The security issue in Mali deteriorated by the terrorist attacks worries Mali and its Western partners. This fear is related to the will expressed by Muslim leaders displaying Islam as a source of social rules. Many observers believe that this will threaten the universal values of democracy.