High accuracy trajectory tracking with constrained inputs is challenging topic in greenhouse indoor environment control. This is due to nonlinearities and inputs/outputs coupling present in physical model of greenhouse. The objective of this study is about the problem of identification and control of a Multi-Input Multi-Output (MIMO) greenhouse process. Proportional Integral (PI) and sliding mode controllers (SMC) are used in conjunction so that estimated outputs tracks desired trajectories with good performance as near as possible in spite of coupled dynamics and outside disturbances climate. To reflect the practical aspect, the constraints of the process and control elements were taken into account .The results demonstrate the feasibility of PISMC control method. Simulation has been done in the environment of Matlab and Simulink; it shows that combined controllers are capable to manage successfully the microclimate of greenhouse.