In this work, the effect of the 2-D Optical Orthogonal Spatial Pattern Codes (OOSPC) is evaluated quantitatively for the transmission of medical images over Multi-core optical fiber using a double blind CDMA technology. The implemented method assumes that P medical practitioners or users are working simultaneously and transmitting images from one site to another. The transmitted images are encoded using a two-steps procedure: 1) coding the pixels (users) using a particular OOSPC and 2) coding the bits using time orthogonal basis functions. The encoding procedure follows the decomposition of an image into its bits to increase the transmission rate by performing a parallel transmission. Then, the encoded information from different images is combined using a multiplexer and is transmitted over the multi-core optical fiber. The transmitted information is de-multiplexed at the receiver side to identify the user that is transmitting the information and consequently, to reconstruct the original image i.e. is decoded using the same double blind Orthogonal Signatures. The performance is quantitatively evaluated using Monte-Carlo simulation techniques using different criteria, namely, the Performance Test, The Bit Error Rate, the Root Mean Square Error and the Pixel Error Rate.