Groundwater studies were carried out in the center of the West Progo Dome, at Kaligesing, Purworejo District, Central Java, and its surrounding area, with an emphasis on hydrochemical problems. As a water-scarce area, groundwater studies are urgently needed in this area. This research is intended as a hydrogeological study with the aim of knowing the conceptual groundwater flow model in the study area. The method used is a field hydrogeological survey as well as hydrochemical and natural isotope analysis supported by chemical and groundwater isotope data. Less clear hydrochemical evolution indicates that the process of groundwater flow is dominant in the local flow system. Groundwater facies is dominated by bicarbonate type, neutral pH, relatively low total dissolved solid (TDS), and electric conductivity (EC), and influenced by season or rainfall. The dominant hydrochemical processes in the groundwater system are leaching, ion exchange, sulfate reduction, and dilution. Groundwater facies is determined by the rock minerals marked by differences in hardness and TDS. Whereas, stable isotope contents of groundwater vary from light to heavy. Springs with light isotopes show the circulation of deep groundwater flow or from a relatively high recharge zone, either locally or from other places around it. Isotopic enrichment in all seasons can occur due to evaporation or mixing with surface water that has undergone previous evapotranspiration, indicated by increasing of heavy isotopes or δD-excess (d) of groundwater. There are two types of groundwater flow patterns, namely shallow and deep groundwater flow patterns. Shallow groundwater is characterized by heavy isotopes, shifted with relatively small d. Deep groundwater circulation pattern is characterized by a consistent, light δD value and appreciable d.