Objective. To estimate the prevalence rate of ocular symptoms and the positive rate of conjunctival swab samples of patients diagnosed with 2019 Novel Coronavirus Disease (COVID-19). Methods. We performed a systematic review and meta-analysis. A comprehensive literature search was done based on PubMed, Embase, MedRxiv, and the Cochrane Library. The primary outcomes are the prevalence rate of conjunctivitis/conjunctival congestion and the positive rate of conjunctival swab samples. Rates were expressed as proportions with 95% confidence intervals (CIs). Results. A total of 12 studies with 1930 participants were included for meta-analysis. The pooled prevalence rate of conjunctivitis/conjunctival congestion was 8% (95% CI: 5%-12%). 1% (95% CI: 1%-4%) of COVID-19 patients were diagnosed with conjunctivitis/conjunctival congestion as the initial symptom. The pooled positive rate of conjunctival swab samples was 3% (95% CI: 2%-5%). We also assessed other ocular symptoms reported in the 12 studies, including foreign body sensation, increased secretion, and eye itching. The pooled prevalence rates were 6% (95% CI: 3%-10%), 10% (95% CI: 8%-12%), and 9% (95% CI: 7%-10%), respectively. Conclusions. The evidence on the positive rate of conjunctival swab samples and the prevalence rates of ocular symptoms indicated that COVID-19 ocular transmission was possible but less likely.

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PurposeBy reporting clinical characteristics and retinal image quality before and after refractive lens replacement surgery in early-onset high myopia (eoHM) patients presenting with partial cataract, we emphasized the need for an objective way to grade the severity of partial cataracts.MethodsThis retrospective, consecutive case series included six Chinese patients (nine eyes). Analysis of previous medical records, visual acuity, optometry, retinal image quality, and axial length (AXL) before surgery and after surgery was performed.ResultsFive females and one male (nine eyes) with a mean (± SD) age of 11.6 ± 7.9 years (range: 4–25 years) were included in this study. The preoperative spherical power ranged from −7.5 to −42 D. The mean follow-up time was 36 months (range: 24–48 months). Phacoemulsification was followed by in-the-bag implantation of intraocular lens. For patients who were under 6 years old, posterior capsulotomy + anterior vitrectomy were performed simultaneously. All surgeries were uneventful and no postoperative complications occurred during the entire follow-up period. All patients’ uncorrected visual acuity improved by ≥2 lines postoperatively(Snellen acuity). LogMAR best-corrected visual acuity was improved at 24-month (P = 0.042) and endpoint (P = 0.046) follow-ups. Modulation transfer function cutoff frequency (MTFcutoff) and objective scatter index (OSI) was significantly improved at 12-month (P = 0.025, P = 0.038), 24-month (P = 0.005, P = 0.007) and endpoint (P = 0.005, P = 0.008) follow-ups. Postoperative AXL remained stable during 2–4 year follow-ups (P > 0.05).ConclusionRefractive lens replacement surgery is safe and effective for improving functional vision in eoHM patients presenting with partial cataract. Retinal image quality could provide a useful and objective way to facilitate partial cataract severity evaluation and surgery decision making.

Background By reporting clinical characteristics and retinal image quality before and after refractive lens replacement surgery in early-onset high myopia (eoHM) patients presenting with partial cataract, we emphasized the need for an objective way to grade the severity of partial cataracts. Methods This retrospective, consecutive case series included six Chinese patients (nine eyes). Analysis of previous medical records, visual acuity, optometry, and axial length (AXL) before surgery and 2–4 years after surgery was performed. Retinal image quality was measured by the Optical Quality Analysis System and recorded as modulation transfer function cutoff frequency (MTFcutoff) and objective scatter index (OSI) at the same time point. Results Five females and one male (nine eyes) with a mean (± SD) age of 11.6 ± 7.9 years were included in this study. The preoperative spherical power ranged from − 7.5 D to -42 D. The mean follow-up time was 36 (36–36) months (range: 24–48 months). Phacoemulsification was followed by in-the-bag implantation of intraocular lens. For younger patients who could not cooperate with postoperative laser capsulotomy, posterior capsulotomy + anterior vitrectomy were performed simultaneously. All surgeries were uneventful and no postoperative complications occurred during the entire follow-up period. Four eyes underwent YAG-laser capsulotomies at 12–18 months postoperatively. Initial spherical correction (treatment achieved) averaged 18.25 ± 11.15 D (range: 7.75-44 D). All patients’ uncorrected visual acuity improved by ≥ 2 lines postoperatively. LogMAR BCVA was significantly improved at 24-month (95%CI: 0.015–0.878, p = 0.042) and endpoint (95%CI: 0.008–0.909, p = 0.046) follow-ups. MTFcutoff and OSI was significantly improved at 12-month (p = 0.025, p = 0.038), 24-month (p = 0.005, p = 0.007) and endpoint (p = 0.005, p = 0.008) follow-ups. Postoperative AXL remained stable during 2–4 year follow-ups compared to the pre-operative value (p༞0.05). Eight eyes (0.89%) exhibited myopia shift (~-0.5 D/year except for case 3), whereas case 5 (age 25) showed hyperopic change. Conclusion Refractive lens replacement surgery is safe and effective for improving functional vision in eoHM patients presenting with partial cataract. Retinal image quality could provide a useful and objective way to facilitate partial cataract severity evaluation and surgery decision making.