Background As the novel coronavirus 2019 (COVID-19) continues its pandemic surge globally along with its social distancing norms , the physical conduction of practical examinations for medical graduates and postgraduates has become difficult. Software-based systems and social media platforms could provide alternatives for ensuring regular medical education and exam-oriented assessments. In this context, we evaluated our own experience with virtual conduction of semester practical exams for medical graduates. Material and Methods This prospective study was conducted in Gynaecology and Obstetrics department. We employed live streaming educational video conferencing software for virtual consultation between medical students, patients (case presentations), internal and external examiners. The outcomes were evaluated in terms of conduction of various components of practical examination—Viva, case presentations, instruments, slides, specimen examination. Statistical analysis was performed by descriptive statistics through Microsoft Excel sheet. Results Virtual conduction examination/evaluation was performed on 150 medical students by examiners from a distant location. No problems occurred except few short duration (less than 5 min) interruptions due to internet connectivity issues. 125/150 (83.5%) of medical students and all examiners (2 internal and 2 external) expressed satisfaction with virtual medical evaluation. Conclusions 83.5% of medical students and all examiners expressed satisfaction with virtual medical evaluation during this COVID pandemic. Our findings suggest that virtual conduction of practical annual medical exams through virtual video conferencing platform appears to be an optimal alternative during COVID pandemic.