Summary:Purpose: The present study was conducted to determine the rate of sudden unexplained death in epilepsy (SUDEP) in a well-defined cohort of patients included in the lamotrigine (LTG) clinical development database.Methods: A panel of scientists experienced in the area of SUDEP was assembled and provided with case summaries on all deaths (n = 45) reported during the initial clinical development of LTG. The panel developed a set of criteria for classifying cases as SUDEP (definite or highly probable), possible SUDEP, or non-SUDEP. This classification algorithm was then applied to the LTG cases, and SUDEP rates were calculated using patient-years of exposure as the denominator.Results: At the time of the study, 4,700 patients (5,747 patient-years of exposure) were included in the worldwide LTG clinical trials database. In this ccihort, 45 deaths were reported.Eighteen were judged by the panel to be SUDEP, 6 were defined as possible SUDEP, 20 were judged to be due to other causes (non-SUDEP), and 1 lacked sufficient data from which to make a classification. The overall SUDEP rate (definite/ highly probable SUDEP and possible SUDEP combined) was calculated to be 3.5 in 1,000 patient-years of exposure to LTG.Conclusions: The rate of SUDEP in this cohort of patients was comparable to the rate that would be expected in young adults with severe epilepsy (the subgroup of patients believed to be at highest risk of SUDEP). The data suggest that the rate of SUDEP in the LTG clinical development program is a function of the clinical trial population and is unrelated to drug treatment. Key Words: Sudden unexplained death in epilepsy-Refractory epilepsy-Partial seizures-Lamotrigine.Sudden unexplained death in epilepsy (SUDEP) is a significant cause of mortality among persons with epilepsy (1-13). Although SUDEP has been reported since the turn of the century (14), the incidence and pathophysiology of this phenomenon are not well understood (8,15). SUDEP is, by definition, a diagnosis of exclusion, which is assigned when no obvious cause, such as trauma, infection, hemorrhage, pulmonary embolism, or myocardial infarct, can be determined and the death occurs in a person with epilepsy who was previously in good health. Such deaths are generally, although not always, unwitnessed, and autopsy is generally required for conclusive categorization (8).