The metabolic syndrome (MS) is a set of metabolic abnormalities increasing the risk of developing diabetes and caridaca coronary disease. The SLC22A1 gene among different population groups, related to carnitine metabolism and acylcarnitine plasma levels associated with metabolic diseases. Objective: To evaluate the rs rs628031 variant in the SLC22A1 gene and its relationship with the metabolic syndrome in women from the state of Guerrero. Methodology: A cross-sectional study was conducted in 438 patients. Anthropometric and biochemical measurements were made. The rapid nonenzymatic technique was used for DNA extraction from leukocytes isolated from peripheral blood for genotyping PCR, using TaqMan probes. Results: a relationship between rs628031 polymorphism and serum total cholesterol proteins was identified in the carriers of the A / A variant with respect to the carriers of the G / G and G / A variant (p 0.0015), in addition to LDL-cholesterole. in carriers of the A / A variant compared to the other genotypes (p = 0.0007).