The whole findings of this systematic review are no more than suggestive of the superiority of early over late tracheostomy because no information of high quality is available for specific subgroups with particular characteristics.

Up-to-date evidence of very low to moderate quality, with insufficient sample power per outcome, does not clearly support the use of procalcitonin-guided antimicrobial therapy to minimize mortality, mechanical ventilation, clinical severity, reinfection or duration of antimicrobial therapy of patients with septic conditions.

Trusted evidence. Informed decisions. Better health. Cochrane Database of Systematic Reviews Analysis 10.1. Comparison 10 Polymerized collagen intralesional injection (0.2 to 1.0 mL / 1.66 to 8.3 mg weekly) × Methylprednisolone subcutaneous injection (maximum dose of 20 mg or 5.0 mL monthly) plus placebo intralesional injection, Outcome

Cochrane Database of Systematic Reviews Data collection and analysisTwo authors extracted data and assessed the methodological quality of the included studies. Meta-analyses using the random-e ects model were conducted for nine outcomes. Relative risk (RR) and mean di erence (MD) or standardized mean di erence (SMD) were used to estimate the treatment e ect, with 95% confidence intervals (CI).

Analysis 5.3. Comparison 5 Live attenuated VZV zoster vaccine versus pneumo 23 vaccine, Outcome 3 41,650 pfu/dose. i Vaccines for preventing herpes zoster in older adults (Review)