Introduction: Acute Flaccid Paralysis (AFP) is a serious condition that causes sudden muscle weakness and loss of deep reflexes. It is important to note that there are various causes of AFP, and one of them is the Guillain-Barré Syndrome (GBS), an autoimmune disorder that affects the nervous system, causing muscle weakness and sometimes paralysis. Objectives: The objective of this study is to compare the cases of cure without sequelae with the cases of cure with sequelae of AFP, based on data obtained between 2007 and 2021, using the records of Notifiable Diseases Information System (SINAN). Methods: A descriptive ecological study was conducted. Data on cure without sequelae and cure with sequelae of AFP were collected from all Brazilian regions between 2007 and 2021. The data were statistically analyzed and compared between the regions. Results: The data obtained indicated a total of 4,784 cases of AFP during the analyzed period, with 3,476 cases (72.6%) resulting in cure without sequelae, while 1,308 cases (27.3%) resulted in cure with sequelae. The Northeast region presented the highest number of cases of cure without sequelae (1,355), while the Southeast region presented the highest number of cases of cure with sequelae (408). The statistical analysis showed a higher proportion of cases of cure without sequelae in all regions. Conclusion: The results of this study demonstrate that cure without sequelae is more frequent than cure with sequelae in the therapeutic approach of AFP in Brazil. The Northeast region presented the highest number of cases of cure without sequelae, while the Southeast region presented the highest number of cases of cure with sequelae. These results highlight the importance of immunization and appropriate treatment of AFP to prevent sequelae and improve the quality of life of patients.