This study aimed to investigate the relationship between red cell distribution width (RDW) and erythrocyte osmotic stability in non‐diabetic and diabetic individuals in both sexes. The study sample (N = 122) was constituted by 53 type 2 diabetics (DM) and 69 non‐diabetics (ND), being 21 and 22 men in each group, respectively. The osmotic stability of erythrocytes was obtained by the variation in saline concentration (dX) capable of determining hypoosmotic lysis. Higher RDW values and lower serum iron concentrations were found in the diabetic group when compared to the non‐diabetic volunteers. In the group of diabetic women, RDW was positively correlated with the reticulocyte index, and both RDW and dX were negatively correlated with iron, haemoglobin, transferrin saturation index, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration. In all the groups studied, RDW was positively correlated with dX, especially in the diabetic group, where the correlation was the strongest. RDW elevation in both women and men with type 2 diabetes mellitus was associated with decreased serum iron indicators. Furthermore, RDW has a similar meaning to dX, as small erythrocytes have less haemoglobin, resulting in both an increase of RDW and dX.

Caloric restriction (CR) reduces body weight and systemic inflammation, but effects on adipose tissue under dietary lipid overload are controversial. We evaluated the effects of CR-induced weight loss with a high-fat diet (HF) on adipose tissue inflammation of obese mice. Male mice were assigned into LF (low-fat diet) and HF. After 8-wk, HF was reassigned for another 7-wk into HF – kept at HF; LFAL - switched from HF to LF ad libitum; RHF - fed HF calorie-restricted to reach LFAL body weight. Serum markers, adipocytokines, morphology, and inflammatory infiltrates in retroperitoneal adipose tissue (RAT) were accessed. LFAL and RHF reduced body weights, equaling to LF. LFAL restored almost all inflammatory markers as LF, except tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and adiponectin. Compared to HF, RHF lowered visceral adiposity, retroperitoneal adipocyte sizes, RAT inflammatory cell infiltration as well as TNF-α, interleukin-6, hepatic and serum C-reactive protein, which were higher than LFAL; adiponectin and MCP-1 did not change. CR with high-fat diet reduced body weight and attenuated visceral adiposity, but did not fully recover visceral tissue inflammation. Novelty bullets • Caloric restriction in a high-fat diet ameliorated visceral adiposity. • Caloric restriction in a high-fat diet did not recover visceral adipose tissue inflammation.

The increase in breast cancer survivors (BCS) has established unprecedented demands on health systems worldwide. In this context, new knowledge is needed to subsidize strategies to handle this population. The objective of this study was to combine the correlations between anthropometric, hematological, biochemical, biophysicochemical, muscle strength, and age variables in BCS. Twenty-two volunteers (51.7 ± 9.2 years old) with a history of mastectomy and lymphadenectomy participated in the study. Among the results, the correlations of the body mass index with lipid profile, strength, and body composition draw special attention. The associations of lipid profile with erythrocyte membrane stability, body composition, and leukocyte count, the associations of the red cell distribution width (RDW) with body mass index, lipid profile, and strength, and the positive correlation between age and leukocyte count also deserve highlights. Such findings allow concluding that investigations that deal singly with health indicators represent a severe limitation in the study of the public in question, and it is necessary to avoid them. The complex network of interactions observed between the various parameters studied reinforces the importance of a global biological analysis of attractive cost-benefit and great practical potential. Teams with medical, nutrition, physical therapy, and physical education professionals, among other areas, can use this knowledge to improve BCS's interdisciplinary approaches in short, medium, and long-term management.

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