In a prospective blind trial in patients undergoing intraabdominal surgery, instillation of povodone iodine (PVI) solution into the wound failed to reduce the incidence of wound sepsis.

A case of papillary adenocarcinoina of the duodenal bulb occurring in a frail, elderly woman is reported, and the literature on carcinoma of the duodenum and the reszilts of surgery is reviewed.

The concept that respiratory failure with its attendant arterial hypoxmnia and iiacreased pulmonary vascular resistance is the principal cause o f death in patients with severe extrathoracic sepsis is supported. I t is postulated that this is a direct result of circulating toxins f r o m the infected area acting on the pulmonary vasculature. T h e principles in management are oidtlined the inefficient run-off through arteriovenous shunting within the inflamed region and elsewhere. Hypoxzmia undoubtedly contributes to this