Aim Low immunogenicity remains a major obstacle in realizing the full potential of cancer vaccines. In this study, we evaluated CpG-coated tumor antigen (Tag)-encapsulating ‘bacteriomimetic’ nanoparticles (CpG-nanoparticle [NP]-Tag NPs) as an approach to enhance anti-tumor immunity. Materials & methods CpG-NP-Tag NPs were synthesized, characterized for their physicochemical properties and tested in vivo. Results We found CpG predosing followed by intraperitoneal (IP) immunization with CpG-NP-Tag NPs significantly attenuated tumor growth in female BALB/c mice compared with respective controls. Histopathological and Immunofluorescence data revealed CpG-NP-Tag tumors had lower proliferation, higher apoptotic activity, greater CD4+ and CD8+ T cell infiltration as well as higher IFN-γ levels as compared with control groups. Conclusion Our findings suggest CpG-NP-Tag NPs can enhance anti-tumor effect of nanoparticulate tumor vaccination system.

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Following publication of the Research Article by Rutika A Kokate, Sanjay I Thamake, Pankaj Chaudhary, Brittney Mott, Sangram Raut, Jamboor K Vishwanatha and Harlan P Jones, titled ‘Enhancement of anti-tumor effect of particulate vaccine delivery system by ‘Bacteriomimetic’ CpG functionalization of poly-lactic-co-glycolic acid nanoparticles’, which appeared in the March 2015 issue of Nanomedicine (Nanomedicine [Lond.]) 10[6], 915–929 [2015]), it has been brought to our attention that Figure 1 was presented incorrectly.The correct presentation is shown above.The authors and editors of Nanomedicine would like to sincerely apologize for any inconvenience or confusion this may have caused our readers.