Objective: Implementing a reform in medical education requires students’ awareness regarding the importance of artificial intelligence (AI) in modern medicine practice. This study aimed to investigate students’ perceptions towards AI in medical education.Subject and Methods: A cross-sectional survey was conducted from June 2021 until November 2021, using an online questionnaire to collect data from medical students in the faculty of medicine at Kuwait University.Results: The response rate was 51.0%, with a sample size of 352. The majority agreed that AI will play an important role in healthcare (349 (99.1%)). More than half of the students understood the basic principles of AI; and 329 (93.4%) students showed comfortability with AI terminology. Many students (329 (83.5%)) believed that learning about AI benefits their careers, and 289 (82.1%) believed that medical students should receive AI teaching.Conclusion: The study reveals students had positive perceptions towards AI. The role of AI in the future of medicine is significant. AI-dominated medical practice is required, and AI will not displace doctors but will create new roles.