Plasmacytoid morphology is often encountered in both lobular and ductal carcinomas of the breast. The presentation of breast carcinoma in patients with a known history of lymphoma or multiple myeloma has been described in the literature. However, to the best of our knowledge, the synchronous presentation of breast carcinoma and multiple myeloma has not been reported. Here we report the first case of the simultaneous occurrence of breast carcinoma with plasmacytoid morphology and multiple myeloma in a 74-year-old patient, which presented challenges in making the diagnosis on fine-needle aspiration biopsy (FNAB) of the breast.

The majority of chondroid tumors arising in the cortex of bone are benign in nature. Juxtacortical chondrosarcoma is a relatively uncommon variant of chondrosarcoma, which by definition, is a malignant cartilaginous tumor that occurs on the surface of bone and measures at least 5 cm. Although the diagnostic value of fine-needle aspiration biopsy is well established, its role in the diagnosis of soft tissue/bone tumors is still not uniformly accepted. Herein, we describe an interesting and controversial case of costal juxtacortical chondrosarcoma presenting as a large intraabdominal mass in a 52-year old female patient, which was diagnosed by fine-needle aspiration biopsy.

In viable motheaten mice, a mutation in the gene encoding the phosphatase, SHP1, causes severe immunodeficiency and autoimmunity. A defective phosphatase may result in modified phosphorylation of proteins involved in gene regulation. Since the NFkappaB/IkappaB proteins are regulated through phosphorylation, we wished to understand if the expression of these proteins was altered by the SHP1 defect. Splenic B cells from viable motheaten mice were isolated and assessed for purity by flow cytometry. Levels of each protein in isolated B cells were examined by Western blot analyses. Measurement of RNA levels for each protein was assessed by semi-quantitative RT-PCR. Western blots revealed that, in me(v) whole cell lysates, there were reduced levels of RelA and RelB proteins and increased levels of p50 and c-Rel. Furthermore, we analyzed the protein levels of IkappaBalpha and found that, in me(v), this inhibitor was significantly reduced, while the level of another member of the IkappaB family, IkappaBbeta, was not. To determine if these findings in me(v) were secondary to the autoimmune process, we evaluated NF-kappaB/IkappaB expression in the BXSB murine model of autoimmunity. Unlike me(v), B cells from BXSB/Yaa mice had NF-kappaB complexes composed of the RelA submit, and IkappaBalpha was readily detected. In addition, RNA for the RelA and IkappaBalpha proteins in me(v) and control littermates was detected by RT-PCR, indicating that the reduced amounts of these proteins was not exclusively due to transcriptional defects. We conclude that the differences in NF-kappaB/IkappaB proteins that we have described in me(v) are likely a consequences of the SHP1 defect and could contribute to the clinical disorder that characterizes me(v) mice.

This case report describes a 54-year-old man who presented to his primary care physician with low back pain. During his workup, an incidental finding of a bladder mass was diagnosed. He underwent transurethral resection of the bladder tumour and the resulting pathology was consistent with extra nodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). Presentation of MALT lymphoma in the urinary bladder is rare. This malignancy is more commonly found in the stomach. The prognosis for this rare tumour is excellent. Our patient showed no sign of recurrence with transurethral excision and radiation alone.