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This study aimed to investigate the efficacy of whole-body vibration training (WBVT) on blood brain-derived neurotrophic factor (BDNF) levels and determine the clinical and functional outcomes in patients with fibromyalgia syndrome (FMS). Thirty-two women with FMS were randomized into an intervention group (IG), receiving 6 weeks of WBVT, or a control group (CG) with no intervention. The outcomes at the baseline and follow-up in both groups included blood BDNF levels, sit-to-stand test (STS), 6-minute walk test (6MWT), Fibromyalgia Impact Questionnaire (FIQ), Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI), and visual analogue scale (VAS). WBVT resulted in a group-by-time interaction effect. Thus, after the intervention time, the IG had increased blood BDNF levels ( p = 0.045 ), a higher number of repetitions on the STS test ( p = 0.011 ), and increased walking distance on the 6MWT ( p = 0.010 ), compared to CG. Moreover, there was a reduction in the scores of the FIQ ( p = 0.001 ), the PSQI ( p = 0.001 ), the BDI ( p = 0.017 ), and pain assessed using VAS ( p = 0.008 ) in IG. The results demonstrate that WBVT promotes an increase in blood BDNF levels, with concomitant improvement in lower limb muscle strength, aerobic capacity, clinical symptoms, and quality of life in women with FMS. This trial is registered with Brazilian Clinical Trials Registry (REBEC; RBR-38nbbx) (https://ensaiosclinicos.gov.br/rg/RBR-38nbbx).

Does whole body vibration exercise improve oxidative stress markers in women with fibromyalgia?J.M. Santos 0 0 0 0 -0 0 0 2 -4 9 9 6 -6 9 7 9 1 , V.A. Mendonc¸a 0 0 0 0 -0 0 0 2 -1 6 9 6 -6 0 9 1 1,2,3 , V.G.C. Ribeiro 0 0 0 0 -0 0 0 3 -3 8 0 9 -7 2 8 5 3 , R. Tossige-Gomes 0 0 0 0 -0 0 0 3 -0 4 2 0 -4 4 5 X 3 , S.F. Fonseca 0 0 0 0 -0 0 0 1 -8 0 2 0 -8 5 1 1 3 , A.C.N. Prates 0 0 0 0 -0 0 0 3 -0 6 0 7 -7 2 8 X 2 , J. Flor 0 0 0 0 -0 0 0 2 -1 4 0 5 -5 1 6 3 2 , A.C.C. Oliveira 0 0 0 0 -0 0 0 2 -5 4 9 1 -6 0 6 0 1 , J.B. Martins 0 0 0 0 -0 0 0 2 -4 1 4 1 -9 7 2 7 2 , B.C.C. Garcia 0 0 0 0 -0 0 0 1 -7 7 9 8 -1 2 4 7 3 , H.R. Leite 0 0 0 0 -0 0 0 1 -8 9 7 7 -8 1 3 1 1,2,3 , P.H.S. Figueiredo0 0 0 0 -0 0 0 2 -6 7 4 8 -3 0 8 1 1,2 , M. Bernardo-Filho0 0 0 0 -0 0 0 2 -4 7 1 8 -4 4 8 X 4 , and A.C.R. Lacerda0 0 0 0 -0 0 0 1 -5 3 6 6 -3 7 5Abstract The objective of this study was to investigate the effect of whole body vibration (WBV) exercise on oxidative stress markers in a group of women with fibromyalgia (FM) compared to a group of healthy women (CT). Twenty-one women diagnosed with FM and 21 age-and weight-matched healthy women were enrolled the study. Plasma oxidative stress markers (primary outcomes) were evaluated at rest and after WBV, and included thiobarbituric acid reactive substances (TBARS), iron reduction capacity (FRAP), superoxide dismutase antioxidant enzymes activity (SOD), and catalase (CAT). At rest, the FM group had higher TBARS (Po0.001) and FRAP (Po0.001), and lower CAT (P=0.005) compared to the CT. In the CT group, the WBV had no effect on TBARS (P=0.559) and FRAP (P=0.926), whereas it increased both SOD (Po0.001) and CAT (Po0.001). In the FM group, the WBV reduced TBARS (p o0.001), FRAP (Po0.001), and CAT (P=0.005), while it increased SOD (P=0.019). There was an interaction effect (moments vs groups) in the TBARS (effect size=1.34), FRAP (effect size=0.93), CAT (effect size=1.45), and SOD (effect size=1.44) (Po0.001). A single trial of WBV exercise improved all oxidant and antioxidant parameters towards a greater adaptation to the stress response in FM women.

Exercise therapy on skeletal muscle of muscular dystrophies has no defined parameters. The effect of low-intensity treadmill training on the oxidative stress markers and fibrosis on hindlimb muscles was investigated. Sixteen dystrophic male mdx animals were separated in trained ( mdx T/n=8) and untrained ( mdx NT/n=8) groups. Wild type animals (WT/n=8) were used as healthy control. The mdx T group runned at a horizontal treadmill (9 m/min, 30 min/day, 3 times/wk, 8 weeks). Gastrocnemius and tibial anterior muscles were collected for analysis of enzymatic/non-enzymatic oxidant activity, oxidative damage concentration, collagen fibers area morphometry. The mdx T group presented a lower collagen fiber area compared to mdx NT for gastrocnemius ( P =0.025) and tibial anterior ( P =0.000). Oxidative damage activity was higher in the mdx T group for both muscles compared to mdx NT. Catalase presented similar activity for tibial anterior ( P =0.527) or gastrocnemius ( P =0.323). Superoxide dismutase ( P =0.003) and total antioxidant capacity ( P =0.024) showed increased activity in the mdx T group at tibial anterior with no difference for gastrocnemius. Low-intensity training is considered therapeutic as it reduces collagen deposition while improving tissue redox status.