: There are several studies investigating the effects of risperidone in autism, but many of these studies are contradictory or inconclusive. This systematic review and meta-analysis investigated the effects of risperidone on five domains of Aberrant Behaviour Checklist (ABC) scale on Autism Spectrum Disorder (ASD), as well as weight gain and waist circumference. The protocol for the present systematic review and meta-analysis was registered on International Prospective Register of Systematic Reviews (PROSPERO). For this study, we analysed articles (2,459), selecting them according to the PICOS strategy (Population, Intervention, Comparison, Outcome, Study design). Although risperidone is effective for the treatment of lethargy and inadequate speech, concerns about the association between weight gain, waist circumference and risperidone require a need to evaluation of the risk-benefit ratio in its use. There was a significant association between weight gain, waist circumference and risperidone. In Conclusion, it was possible to suggest the efficacy of risperidone for the treatment of lethargy and inadequate speech. Finally, we emphasize that the risk-benefit in its use should be evaluated. Protocol number CRD42019122316.

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Cannabis-based products are still not produced in many countries and the great need makes them imported, and often expensive. As an objective, a low-cost extraction method was proposed to facilitate access to the medicinal effects of cannabidiol. The samples of Cannabis sativa used were obtained from in vitro cultivation or from commercially purchased products. Two extraction techniques (ultrasonic extraction and turbo-extraction) and two solvent systems (methanol:chloroform and ethanol) were evaluated. The levels of cannabinoids, total phenolics and total flavonoids were evaluated. The best results were obtained with the turbo-extraction. Ethanol showed a higher yield of cannabinoids, in addition to being a solvent accepted in international conventions in reducing the use of toxic solvents to the environment. Turbo-extraction with ethanol proved to be effective, economical and in line with environmental concerns in the use of ecologically sustainable solvents. As future possibilities, it is proposed to use the information obtained in this study as part of the process of obtaining and subsequent analysis of Cannabis extracts for medicinal purposes.

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