Objectives: This article seeks to identify neuroanatomical differences in ADHD through an overview of systematic reviews that report encephalic differences compared to a control group in volume, area, activation likelihood or chemical composition. Methods: We conducted a systematic search using Cochrane guidelines and PRISMA criteria in PubMed, Scopus, Web of Science, Cochrane Database of Systematic Reviews and Database of Abstracts of Reviews of Effects. Results: Results revealed broad encephalic involvement that includes a functional frontal and cingulate hypoactivation and structural differences in corpus callosum, cerebellum and basal nuclei. Conclusions: ADHD symptoms might be due to a multi-network unbalanced functioning hypothesis. Attention-deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders (Polanczyk, Salum, Sugaya, Caye, & Rohde, 2015). Although no biomarkers have been linked, neuroanatomical differences have been one of the most investigated topics for several decades (Tannock, 1998), providing support for several, yet inconclusive large-scale brain network implications (Castellanos & Proal, 2012) and models (Kofler et al., 2013; Sonuga-Barke, 2005). Neuroimaging developments and new methods have increased our understanding of the underlying neurobiology of ADHD (Rubia, Alegria, & Brinson, 2014a). We have identified 94 reviews related to ADHD neuroanatomy: 54 qualitative reviews and 40 systematic reviews (26 with meta-analysis). Given this volume of scientific information, we aimed to identify the neuroanatomical differences in ADHD through an overview of systematic reviews that report encephalic differences in terms of volume, area, activation likelihood or chemical composition. Materials and methods This review was conducted following the guidelines from the Cochrane Handbook for Systematic Reviews of Interventions (The Cochrane Collaboration, 2011). Other suggestions were also considered (