At the end of the electrophoresis (hanging-strip technique) the paper was dried and the haemoglobm bands were photographed unstained.Mrs. K. and in Mrs. P. However, in our experience a rise of the haemoglobin A2 level may be indicative of thalassaemia, but a normal haemoglobin A2 level does not exclude this condition. Summary Haemoglobin J was seen in two unrelated women of Gujerati-speaking Lohana stock. In one of them the haemoglobin J trait was present together with thalassaemia minor. There was no evidence for a detrimental interaction between the genes for thalassaemia and for haemoglobin J-that is, for a hypothetical haemoglobin J thalassaemia disease.

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This paper describes two infants with congenital enlargement of the thyroid and hepatosplenomegaly. One infant died at birth from obstetrical causes, the other lived for 33 days, during which time he was thyrotoxic and jaundiced. Though the first infant was not jaundiced, and, naturally, showed no signs of thyrotoxicosis, we consider that he showed all the other features of the syndrome. Maternal History Both infants were the offspring of mothers who had undergone thyroidectomy for Graves's disease, two years and four years respectively, before the birth of the affected infant. In both mothers the course of the thyrotoxicosis was unusual in that there was no weight loss during the course of the disease and the exophthalmos persisted unchanged after operation. We consider that both women had a supra-thyroid (pituitary) type of 460 copyright.

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