SummaryBackground/Aim: to examine the connection of H. Pylori in saliva and biopsy material with oral lesions.Material and Methods: Sixty patients with dyspeptic complaints were followed up at the Clinic for Gastroenterology at University Medical Clinical Centre in Skopje, divided into two groups: first group consisted of 30 patients without presence of H. pylori, and the second group with 30 subjects and presence of H. pylori. The presence or absence of H. pylori has been ascertained after endoscopic examination-gastroscopy, and implemented urease test (CLO-test). All patients were clinically followed in order to determinate mouth burning, recurrent aphthous stomatitis (RAS), acid taste and lingual papillary hyperplasia according to Cohen and Proctor. The presence of H. pylori in saliva has been ascertained before endoscopic examination, after chewing Orbit gum without sugar for 1 min using by Pronto dry test. Determination of H. pylori in biopsy material has been ascertained by rapid urease test (RUT).Results: At 30 patients with dyspeptic complaints and presence of Helicobacter pylori, 16 patients (53,33%) had lingual papillary hyperplasia, acid taste, burning mouth and recurrent aphthous stomatitis (RAS). At 4 patients (13,33%) was confirmed acid taste, and also at 4 patients (13,33%) burning mouth. At 2 patients (6,67%) was confirmed lingual papillary hyperplasia, burning mouth, and recurrent aphthous stomatitis (RAS). At the same time, at 2 patients (6,67%) was confirmed burning mouth, and recurrent aphthous stomatitis (RAS), until at 1 patient (3,33%) lingual papillary hyperplasia, as at 1 patient (3,33%) lingual papillary hyperplasia and acid taste. At patients without presence of Helicobacter pylori but with dyspeptic complaints, was confirmed burning mouth in 14 patients (46,67%), lingual papillary hyperplasia, burning mouth, and acid taste in 7 patients (23,33%); in 3 patients (10,00) lingual papillary hyperplasia, burning mouth, and in 2 patients (6,67%) was confirmed recurrent aphthous stomatitis (RAS). Acid taste was registered in 2 patients (6,67%), and also lingual papillary hyperplasia in 2 patients (6,67%). There was a significant differences in clinical aspect between the patients with and without presence of H. pylori, for p< 0,01(p= 0,002); Pearson Chi-square= 20,10 и and p<0,05(p= 0,01).Conclusions: H. pylori in saliva and biopsy material detected with CLO test are reason for oral lesions at patients with dyspeptic complaints who have the presence of H. pylori.

SummaryBackground/Aim: Oral cancer is one of the ten most common cancers in the world, recently positioned as a sixth one, unfortunately with poor prognosis after treatment because of the late diagnostics in advanced stages of the disease. Aim of this study was to present the basic criteria in assessment the accuracy/efficacy, specificity and sensitivity, the positive and negative predicted values of the conventional oral examination (COE) as the easiest and most acceptable procedure in detection of the early changes of the suspicious oral tissue changes compared to the diagnostic gold standard – tissue biopsy in two different groups of examinees.Material and Methods: Sixty patients divided into two study groups (one with potentially malignant oral lesions and a second consisted of clinically suspicious oral cancer lesions) were examined with COE and subjected to histopathological confirmation - tissue biopsy. All examined patients underwent the diagnostic protocol by the American Joint Commission on Cancer, selected under certain inclusion and exclusion criteria.Results: Sensitivity of COE in the group of examinees with oral potentially malignant lesions is 83.33%, its specificity is 20.83%, the positive predictive value is 20.83% and the negative predictive value is 83.33%. The accuracy of the COE method is 33.33%. The sensitivity, in the group of patients with oral cancer is 96.43%, specificity is 0%, the positive predictive value is 93.10% and the negative predictive value is 0%. The accuracy of this method is 90%.Conclusions: The accuracy reaches a value over 90% for the group with lesions with highly suspected malignant potential – oral cancer, and sets the thesis that COE as screening method for oral cancer or premalignant tissue changes is more valuable for the patients with advanced oral epithelial changes, but is recommended to be combined with some other type of screening procedure in order to gain relevant results applicable in the everyday clinical practice.

Residual cysts are common after the extraction of a third impacted molar. Many of them are usually asymptomatic and can be detected incidentally on routine radiography before symptoms appear. Lately, 3D CBCT is the most common diagnostic method for detecting them.We present a case of a residual cyst that exists 20 years after extraction of the right lower third molar. Cysts can vary in size, and over the years can grow and disrupt bone continuity. In this case, a 53year-old patient has painless swelling that manifests extra-orally in the buccal and masseteric regions.It has been recurring in recent years but the condition was improving with the administration of antibiotic therapy. Surgical treatment is the method of choice.Diagnosis and management of the patient are discussed.

Significant vital functions take place in the oral cavity and oropharynx, primarily mastication, as the initial function of the gastrointestinal system, swallowing, respiration and speech.All these vital biological functions can be endangered, ie aggravated, and even disabled by the appearance of neoplasms in that anatomical space. In the maxillofacial region, neoplasms can originate from a variety of tissues, from the mucous membranes of the oral cavity to the jaws, salivary glands, and even tumors of odontogenic origin.However, the most common tumor in the oral cavity is squamous cell carcinoma (OSSC), which originates from the oral mucosa.To determine the accuracy, sensitivity (Se) and specificity (Sp) of the Velscope screening method in the detection of premalignant and initial malignant lesions compared to the gold standard surgical biopsy.The study group consisted of 60 patients divided into two groups. The first group was formed by 30 patients with potentially malignant oral lesions (PML). Another 30 patients with preliminary diagnosis -oral cancer (OC) were included in the second group of examinees.The high sensitivity value of 92.86% and the accuracy of the method of 86.67% largely confirm the reliability and efficacy of the Velscope method in patients with highly suspected oral cancer lesions (OC), significantly more, comparing to the group of premalignant lesions.

Клучни зборови: орални преканцерози; орален карцином; визуелни средства и молекуларни биолошки маркери. Извадок ОСНОВА:Оралните премалигни и малигни лезии бележат тенденција на доцна детекција, која е на штета на пациентите поради високите стапки на морбидитет и морталитет.. Токму затоа е важно раното дијагностицирање на овие нарушувања и заболувања. ЦЕЛ:Целта на овој труд е да ги евалуираме дијагностичките средства и методи за детекција на премалигните и малигни орални лезии. МАТЕРИЈАЛ И МЕТОДИ:За изработка на овој труд, спроведовме автоматско детално пребарување на интернет базата PubMed за периодот од 1966 година до 2014 година. Клучни зборови според кои го изведовме пребарувањето беа: "орални преканцерози, орален карцином, визуелни средства и молекуларни биолошки маркери". Ги вклучивме и извештаите кои беа рецензирани и прифатени за објавување, а сеуште неиспечатени. Ги исклучивме статиите кои беа известувања од експерти, како и оние кои не беа од англиско издание или не беа изведени на хумани субјекти. РЕЗУЛТАТИ:Од најчесто употребуваните техники и дијагностички тестови, виталните ткивни боења покажуваат сензитивност од 93.5% -97.8% и нешто пониска специфичност од 73.3% -92.9%. Употребата на современите алатки за визуелизација на ткивните аберации, бележат сензитивност од околу 30% и специфичност од 63%. ЗАКЛУЧОК:Оралната цитологија, патохистолошкиот наод, молекуларните биолошки испитувања, како и примената на софистицирани визуелни средства во детекција на суспектните орални лезии, се смета дека ќе доведат до рано дијагностицирање и ќе го направи толкувањето на наодите далеку посигурно отколку порано. Abstract BACKGROUND:Oral cancer has a tendency to be detected at late stage which is detrimental to the patients because of its high mortality and morbidity rates. Early detection of oral cancer is therefore important to reduce the burden of this devastating disease.