Decline in the biological response to insulin in the presence of normal or high blood concentrations of the hormone is called insulin resistance (IR) [1]. This could be reflective of an insensitivity of peripheral tissues (e.g., muscle, liver, adipose tissue) to the effects of insulin [2] or due to reduction in the maximal response to the hormone [1]. Obesity in adults is linked to IR. In 2011-2012, the US prevalence of overweight/obese children 12-19 years old of all races was 34.5% [3]. Excess weight in youth is a strong predictor of excess weight in adulthood [4,5]. It also is associated with an increased risk of cardiovascular disease and type 2 diabetes [6,7] and a greater likelihood of mortality from those conditions [8]. Furthermore, even among individuals with normal Abstract Purpose: To develop a valid method to identify insulin resistance (IR) in overweight and obese adolescents without requiring a fasting blood sample.