Research into the chronic wound environment has led to an improved understanding of the molecular and cellular processes occurring at the wound bed, culminating in the concept of wound bed preparation. This paper discusses the role of proteases and pH in wound healing, and proposes that pH may influence healing outcomes.

The bifluoride complex, trans-[Ru(dmpe) 2 (H)(HF 2 )] (dmpe = Me 2 PCH 2 CH 2 PMe 2 ), is generated by reaction of cis-[Ru(dmpe) 2 H 2 ] either with fluoroarenes (C 6 F 6 , C 6 F 5 H and others) or by reaction with Et 3 N•3HF; its solid-state structure, established crystallographically, reveals a Ru(h 1 -FHF) moiety with a long Ru-F bond and an F•••F distance close to that in bifluoride salts, while the presence of the same complex in solution is shown by low-temperature NMR spectra.

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The four triimine compounds cis,cis-1,3,5-tris[(E)-(X)-benzylideneamino]cyclohexane [X ) H (1); 3-hydroxy (2); 3,5-dimethoxy (3); 4-acetamido (4)] are synthesized by the condensation of cis,cis-1,3,5-triaminocyclohexane with a substituted aromatic aldehyde. Complexation of these ligands with metal salts (1 with Ni, Cu, and Zn salts; 2 and 3 with Cu salts; 4 with a Zn salt) causes a selective hydrolysis reaction producing new monoimine complexes. The resulting complexes are characterized by a combination of infrared spectroscopy, elemental analysis, mass spectrometry and, in the cases of the zinc complexes, 1 H NMR spectroscopy. The structures of all six complexes are confirmed by single-crystal X-ray crystallographic studies.