The most consistent and severe hemodynamic reserve abnormalities observed in patients with HFpEF were impairment in chronotropic reserve and exaggerated increase in pulmonary capillary wedge pressure with exercise. These may be important targets for therapeutic strategies to improve exercise tolerance in patients with HFpEF.

Objective: To investigate the effectiveness of exercise and pharmacotherapy interventions in reducing visceral adipose tissue (VAT). Patients and Methods:A systematic search of OVID, MEDLINE, SCOPUS, Web of Science, Cochrane Library, ClinicalTrials.gov, New York Academy of Science Grey Literature Report, and Open Grey was combined with hand searches of existing literature. 2,515 titles and abstracts were reviewed. Only randomized controlled trials (RCTs) evaluating the efficacy of monitored exercise or pharmacological interventions for VAT reduction using CT or MRI imaging during a sustained intervention period (≥6 months) were included. Data were independently extracted by reviewers according to PRISMA guidelines and assessed using for quality and risk of bias. Separate analyses for each intervention were performed using random-effect models with pooled estimates of the

This paper presents a 50 Gb/s per lane hybrid BiC-MOS and silicon photonic integrated circuit for use in fiber optic communications. Fine pitch copper pillars are used to integrate electronics and silicon photonics. The resulting device demonstrates the generation and detection of up to 56 Gb/s NRZ optical signals over 2-km standard single-mode fiber at 1310-nm wavelength. At 40 Gb/s, the link operates error free, and at 56 Gb/s well below KR4 RS-FEC operating BER. The power dissipation of TX including CW laser is 600 mW (450-mW driver, 150-mW CW laser), RX is 150 mW, resulting in total per channel of less than 750 mW.

We present a two-axis electrostatic MEMS scanner with high-reflectivity monolithic single-crystal-silicon photonic crystal (PC) mirrors suitable for applications in harsh environments. The reflective surfaces of the MEMS scanner are transfer-printed PC mirrors with low polarization dependence, low angular dependence, and reflectivity over 85% in the wavelength range of 1490nm~1505nm and above 90% over the wavelength band of 1550~1570nm. In static mode, the scanner has total scan range of 10.2° on one rotation axis and 7.8° on the other. Dynamic operation on resonance increase the scan range to 21° at 608Hz around the outer rotation axis and 9.5° at 1.73kHz about the inner rotation axis.

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