Objective: Manual searches are supplemental approaches to database searches to identify additional primary studies for systematic reviews. The authors argue that these manual approaches, in particular hand-searching and perusing reference lists, are often considered the same yet lead to different outcomes.Methods: We conducted a PubMed search for systematic reviews in the top 10 dermatology journals (January 2006-January 2016. After screening, the final sample comprised 292 reviews. Statements related to manual searches were extracted from each review and categorized by the primary and secondary authors. Each statement was categorized as either ''Search of Reference List,'' ''Hand Search,'' ''Both,'' or ''Unclear.''Results: Of the 292 systematic reviews included in our sample, 143 reviews (48.97%) did not report a hand-search or scan of reference lists. One-hundred thirty-six reviews (46.58%) reported searches of reference lists, while 4 reviews (1.37%) reported systematic hand-searches. Three reviews (1.03%) reported use of both hand-searches and scanning reference lists. Six reviews (2.05%) were classified as unclear due to vague wording.Conclusions: Authors of systematic reviews published in dermatology journals in our study sample scanned reference lists more frequently than they conducted hand-searches, possibly contributing to biased search outcomes. We encourage systematic reviewers to routinely practice hand-searching in order to minimize bias. Well-conducted systematic reviews are the apex of the evidence hierarchy and routinely used for developing care guidelines and informing clinical decision making [1]. While each aspect of systematic review methodology is important, the search process, when thorough and well produced, leads to a set of research evidence to consider for inclusion that minimizes bias. There is a substantial body of evidence pointing to the importance of thorough and prespecified search strategies involving multiple databases to locate relevant studies and minimize the potential for publication and language bias [2]. As part of the search process, systematic reviewers often review reference lists of other studies or conduct hand-searches to identify additional primary studies. It is the authors' experience that reviewing reference lists and conducting hand-searches are often considered the same, yet we argue that these processes are quite different and lead to different outcomes.Our objective was to assess how often systematic reviewers in dermatology actually conducted handsearches when performing a systematic review.