Synthesis of biologically promising heterocyclic scaffolds under greener conditions is one of the most promising areas of research today in organic chemistry. Heterogeneous catalysis has received greater attention versus homogeneous catalysis as it is much more beneficial in terms of reusability of the catalysts. Among many others, various heteropoly acids have been used as efficient heterogeneous catalysts for diverse organic transformations. In the present review, we have summarized the literature related to the synthesis of various biologically promising heterocyclic scaffolds utilizing a catalytic amount of one such efficient and reusable heteropoly acid, the Preyssler catalyst.