The assessment of the economic performance of any economic sector can also be achieved through the structural analysis of the profit, this being the final result of the activity of a company and a measure of its efficiency. The structural analysis of tourism profit can provide us relevant information regarding the viability of this economic sector and its contribution to the local economies. In this study we intend to analyze the tourism profit from the South-East Development Region, from a structural point of view, in order to identify those tourism sectors that have the biggest contribution to the total tourism profit in this region. Thus, a tourism profit database was created for each territorial administrative unit in the South-East Development Region, at the four-digit NACE code level, for the period 2000-2018. Subsequently, the database was used to make graphical representations from an evolutionary point of view. The applied methodology highlighted a positive evolution, for the entire period analyzed, of the profit obtained from tourism in total profit achieved at the region level.