Background : The incidence of colorectal malignancies at a young age, and the absence of sufficient data to explain about it, including in terms of gene mutations that play a role. The research will be done here is to determine whether changes in mRNA expression of genes DCC ( deleted in colorectal cancer ) and p53 play a role in colorectal malignancy is less than 40 years of age. Researchers also will perform immunohistochemistry to look at protein expression of the gene and protein expression was evaluated whether these correlated with mRNA expression.

Background: Pancreatic adenocarcinoma has poor overall prognosis even after radical surgery, although a few patients may achieve 5 or 10-year survival following radical resection. We reported the short-term period survival (1-year survival) of the patients with Pancreatic Adeno Carcinoma which had been performed resection in our low volume center. Case report:During 2015, we performed five resections of pancreatic adenocarcinoma (pancreaticoduodenectomy) in our teaching hospital. One patient was male, and the rest were female with the average of age 42 -64 years old. Pyloric preserving pancreaticoduodenectomy (PPPD) had been done in 2 cases. The average length of stay (LOS) was 10.2 days. We found two postoperative complications, both of them were classified into Clavien-Dindo 2. R0 resection can be achieved in 4 patients; one patient had an R1 resection. All of the patients received postoperative adjuvant chemotherapy with gemcitabine. After one year follow up, four patients have survived with good quality of life and one patient did not survive due to pneumonia. Conclusion: Resection of pancreatic adenocarcinoma can be performed safely in low volume center with attention in a multidisciplinary approach to get the better outcome.