Purpose/Background: Glucagon-like peptide-1 (GLP-1) is a molecule used to treat type 2 diabetes mellitus (T2DM). Given their widespread expression in the nervous system, GLP-1 receptors also play a role in regulating mood and cognitive function. Here, we aimed to compare obese patients with T2DM, with or without exenatide (a GLP-1R agonist) use on cognitive and affective functioning. Methods/Procedures: A total of 43 patients with T2DM (23 on exenatide and 20 without exenatide) were evaluated with the Snaith-Hamilton Pleasure Scale, Cognitive Failures Questionnaire, Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7, Childhood Trauma Questionnaire, Perceived Stress Scale (PSS), and Chronic Stress Scale, in addition to laboratory-based measures of reward learning (the probabilistic reward task) and working memory (Letter-N-Back task).Findings/Results: Patients on exenatide had higher body mass index (
Children living in armed conflict zones are often exposed to political violence and other risk factors that may be caused or exacerbated by the conflict, such as poverty and family violence. If left untreated, these experiences may cause psychological problems throughout life. This study investigates the psychological well-being of children living in the low-intensity armed conflict zone in Turkey in relation to their adverse experiences. We collected data from 409 caregivers for their children (236 girls) aged 5.5 to 18 years (M = 11.50, SD = 3.65). Caregivers provided information regarding their children's emotional and behavioral problems (internalizing, externalizing and total problems, post-traumatic stress symptoms -PTSS), income, family violence and armed conflict experiences. Caregivers reported moderate levels of problems among children. The prevalence of subclinical/clinical (T ≥ 60) scores were 14.3% for internalizing, 12.6% for externalizing and 14% for total problems, and 7.9% for PTSS. Notably, almost all families resided in extreme poverty. The prevalence of family violence was 36%.Children were frequently exposed to conflict-related events. Hierarchical regressions showed that, after controlling for the role of demographic variables and other risk factors, income predicted total problem level ( = -.10), and family violence ('s = .17 to .26) and armed conflict ('s = .13 to .20) experiences predicted internalizing, externalizing and total problems, and PTSS levels. Our findings suggest that family violence and armed conflict pose a significant risk to children's psychological well-being and inform intervention strategies and policy decisions to promote welfare in such disadvantaged contexts.
Acknowledgments: This study was funded by the Patrice L. Engle Dissertation Grant for Global Early Child Development from the Society for Research in Child Development awarded to the first author. We would like to thank the parents and children who participated in the study, and the research assistants who helped with data collection. Conflict of Interest: The authors declare that they have no conflict of interest.This version of the article has been accepted for publication, after peer review but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections.
Socioeconomic status is a strong predictor of normative development and well-being in young people. It is well-known that growing up in a socioeconomically disadvantaged context may lead to negative outcomes, both in childhood and in adulthood. Early intervention and prevention programmes are crucial for building resilience and improving health, well-being and equity. Bounce Forward is a school-based prevention programme implemented in Blackpool, a town in the United Kingdom facing multiple challenges. It was part of a whole town resilience approach and nascent global social movement known as the “Resilience Revolution.” Between 2017 and 2019, the programme was delivered in all Year 5 classes at every primary school in Blackpool (nschool = 36), reaching out to 3,134 students (ages 9–10; 50.4% male). The programme aimed to increase resilience in young people by building knowledge and skills about mental health and resilience through 10 sessions. In the current study, we longitudinally examined a range of protective factors, which are relevant to young people's resilience, as well as their mental health outcomes at three time points: before they participated in Bounce Forward, at the end of the programme, and 3–5 months later, when they started Year 6. The current sample included 441 Year 5 students (54.2% male) from 11 primary schools in Blackpool. Nineteen teaching staff also participated in the study and provided qualitative data regarding the impact of the programme on their students. Results showed improvement in some areas of young people's resilience after taking part in Bounce Forward. We also identified gender differences in several protective factors, indicating that boys may need further support. Teaching staff highlighted improvements in various areas; and also observed that their students have been using the strategies that they learnt from the programme. Altogether, findings suggested that young people benefitted from Bounce Forward. The programme is sustainable, offering a free to download teacher resource pack that allows schools to self-deliver it.
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