<p>Recently people appealing for peripheral coldness increase. Lycium fruits have a long tradition of use in nutrition and traditional medicine in East Asia, while its effect on peripheral coldness is not yet investigated. We study the effects of lycium and lycium-rich formula (Ligustrum lucidum ait, LLA) on the peripheral coldness induced by local cooling in mice.</p><p>7-week old male ddY mice were administered either water (control) or lycium or LLA for 2 weeks. After an aesthesia, the mouse body except for head was immersed into 10 ℃ water for 10 min. Then the skin surface and rectal temperature of mouse were measured with a thermocamera and a thermocouple thermometer, respectively. And two laser Doppler flow probes were set to measure the skin blood flow of plantar and tail, respectively.</p><p>In the case of 1-week administration on mice, 10% lycium- and 10% LLA-treatments showed good recovery of whole body surface temperature measured by a thermocamera. After 2-week administration on mice, there were not significant differences in the recovery rates of rectal temperature compared with those of the control group. And the 30 min- and 50 min-recovery rates of dorsal skin surface temperature by 1% and 10% lycium-treatment were significantly higher than those of the respective control. Further, the 30 min- and 50 min-plantar skin blood flow by 10% LLA-treatment were significantly higher than those of the respective control. The 50 min-tail skin blood flow by 10% LLA-treatment and 60 min-tail skin blood flow by 1% LLA-treatment were significantly higher than those of the control, respectively.</p>It can be concluded that the administration of lycium or LLA on mouse led to an increase of peripheral blood blow, and thus a recovery of skin surface temperature.