A novel multi-level read-only recording using signal waveform modulation (SWM) is presented. The SWM is realized by inserting a sub-pit/sub-land to the original land/pit. Numerical simulation provides a helpful tool for the write strategy optimization. This method is experimentally validated on the DVD platform. Comparing with 2-level recording, an increase of 50% in capacity can be expected. It shows superiority over signal amplitude modulation (SAM) multi-level in replication processing, capacity increase and servo performance.

Abstract. The interaction between bioactive small molecule ligands and proteins is one of the important research areas in proteomics. Herein, a simple and rapid method is established to screen small ligands that bind to proteins. We designed an agarose slide to immobilize different proteins. The protein microarrays were allowed to interact with different small ligands, and after washing, the microarrays were screened by desorption electrospray ionization mass spectrometry (DESI MS). This method can be applied to screen specific protein binding ligands and was shown for seven proteins and 34 known ligands for these proteins. In addition, a high-throughput screening was achieved, with the analysis requiring approximately 4 s for one sample spot. We then applied this method to determine the binding between the important protein matrix metalloproteinase-9 (MMP-9) and 88 small compounds. The molecular docking results confirmed the MS results, demonstrating that this method is suitable for the rapid and accurate screening of ligands binding to proteins.

A lens actuator is an important mechanical-electrical component in optical pickup. For the high-sensitivity actuator used in a super-multi recorder, a novel magnetic circuit is proposed in this paper. This magnetic circuit consists of six thick permanent magnets with regulated placement, two thin permanent magnets, a base yoke, and an upper yoke. Experimental results verified the feasibility of the designed magnetic circuit.

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