Introduction/aims: Cardiopulmonary arrest can occur with different rhythms in in-hospital and out-of-hospital cases. Early and effective cardiopulmonary resuscitation (CPR) is the most important practice affecting survival in these patients. It was aimed to determine the relation of fetuin-A level, which is a new protein, with the collapse rhythm, prognosis, and mortality in patients who underwent CPR. Methods: One hundred four patients who had cardiopulmonary arrest as witnesses in the emergency department were included in prospective study. The patients were divided into four groups according to their collapse rhythm: asystole, pulseless electrical activity, pulseless ventricular tachycardia, and ventricular fibrillation. According to the mortality status, they were divided into three groups as alive, exitus at the emergency department (EXED), and exitus at intensive care unit (EXIC). Results: The average age of the patients included in the study was 63.38±12.38 years, 42 (40%) of them were women. Fetuin-A was 0.183±0.18 ng/ml in the EXED group, 0.183±0.22 ng/ml in the EXIC group, and 0.201±0.16 ng/ml in the survival group (p=0.001). The fetuin-A level was the highest in the pulseless electrical activity group with 0.206±0.10 ng/ml and the lowest in the ventricular fibrillation group with a value of 0.183±0.20 ng/ml (p=0.002). There was a strong negative correlation between fetuin-A and rhythm (p=0.001). Conclusion: In cardiopulmonary resuscitated patients, the fetuin-A level may be a helpful value in defining prognosis and mortality.

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