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Oxybutynin is one of the most commonly prescribed drugs in overactive bladder treatment. Because of its lipophilic structure, it crosses the blood-brain barrier and causes cognitive side effects in the central nervous system. Abuse of the drug is due to its hallucinogenic effect. In terms of substance use disorder, adolescents are one of the groups at risk. In addition to well-known addictive substances, drugs which have sedative, anticholinergic-antimuscarinic, stimulant properties and prescribed for any treatment also can be abused in adolescents with substance abuse. In this article, it is aimed to raise awareness of physicians and health workers about oxybutynin abuse because of the pharmacodynamic characteristics of the drug and its effects on the central nervous system. The health professionals should therefore prescribe this drug with more attention and follow-up those patients.

Objective: Arterial spin labeling (ASL) is a relatively new imaging modality in the field of the cognitive neuroscience. In the present study, we aimed to compare the dynamic regional cerebral blood flow alterations of children with ADHD and healthy controls during a neurocognitive task by using eventrelated ASL scanning. Methods: The study comprised of 17 healthy controls and 20 children with ADHD. The study subjects were scanned on 3 Tesla MRI scanner to obtain ASL imaging data. Subjects performed go/no-go task during the ASL image acquisition. The image analyses were performed by FEAT (fMRI Expert Analysis Tool) Version 6. Results: The mean age was 10.88 ± 1.45 and 11 ± 1.91 for the control and ADHD group, respectively (p ¼ .112). The go/no-go task was utilized during the ASL scanning. The right anterior cingulate cortex (BA32) extending into the frontopolar and orbitofrontal cortices (BA10 and 11) displayed greater activation in ADHD children relative to the control counterparts (p < .001). With a lenient significance threshold, greater activation was revealed in the right-sided frontoparietal regions during the go session, and in the left precuneus during the no-go session. Conclusion:These results indicate that children with ADHD needed to over-activate frontopolar cortex, anterior cingulate as well as the dorsal and ventral attention networks to compensate for the attention demanded in a given cognitive task.