Introduction Despite the controversy about the benefits of dietary supplements in treating or preventing COVID-19, their use has increased worldwide even with the introduction of relevant vaccines. Thus, this study aimed to investigate the perception of Middle Eastern Arab publics of dietary supplements as prophylactic or therapeutic agents against COVID-19, and their consumption during the second wave of COVID-19 pandemic. Methods A validated, pilot tested online survey was distributed through social networking platforms in Lebanon, the Kingdom of Saudi Arabia, Palestine, Jordan, and the United Arab Emirates. Responses underwent various statistical analyses. Results A total of 2,100 responses were included. Around 44% of participants reported changes in their dietary behavior during COVID-19, and 70% believed that healthy habits may prevent the infection. Moreover, 21% believed that dietary supplements surely protect against COVID-19 and 45% thought they aid in treating it. Users of supplements during the second wave of the pandemic counted for 47%, who declared they were influenced by the media, healthcare providers, or close people. The most used supplements included Vitamins C and D and zinc. Only 34% of participants were reading supplement leaflets. The use of supplements was significantly correlated with females and exercisers, as revealed by the odds ratio and logistic regression analysis. Conclusions In line with other areas of the world, the use of dietary supplements in the Middle East against COVID-19 is not evidence-based. Competent health authorities should play their role in spreading sound awareness among the public regarding this issue.