PurposeIn this nationwide 5-year longitudinal population-based study, we aimed at investigating the incidence of lung cancer among patients with interstitial lung disease.Materials and MethodsData was collected from the Korean National Health Insurance Research Database from 49,773,195 Korean residents in 2009. Thirteen thousand six hundred and sixty-six patients with interstitial lung disease diagnosed January-December 2009. The end of follow-up was June 30, 2014. Up to four matching chronic obstructive pulmonary disease controls were selected to compare the lung cancer high-risk group based on age, sex, diagnosis date (within 30 days), and hospital size. The number of patients with newly developed lung cancer was determined.ResultsThe incidences of lung cancer were 126.98, 156.62, and 370.38 cases per 10,000 person-years (2,732, 809, and 967 cases of cancer, respectively) in the chronic obstructive pulmonary disease, interstitial lung disease, and chronic obstructive pulmonary disease with interstitial lung disease groups, respectively. Of the 879 patients with idiopathic pulmonary fibrosis, 112 developed lung cancer (incidence, 381.00 cases per 10,000 person-years).ConclusionIncidence of lung cancer among patients with interstitial lung disease was high. Interstitial lung diseases have a high potential for developing into lung cancer, even when concurrent with chronic obstructive pulmonary disease.

High-performance membranes are prepared based on UiO-66-NH2 nanoparticles dispersed in an adhesive PGMA-co-POEM comb-like copolymer. The membranes show excellent separation performance (CO2 permeance of 1320 GPU and CO2/N2 selectivity of 30.8).

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We report a high performance CO 2 capture membrane based on the copolymerization and self-cross-linking of poly(glycidyl methacrylate-g-poly-(propylene glycol))-co-poly(oxyethylene methacrylate) (PGP−POEM) comb copolymer. The epoxide−amine reaction is responsible for the self-cross-linking reaction, which takes place under mild conditions without any additional crosslinkers or catalysts. The effects of self-cross-linking on the membrane properties are investigated by comparing the copolymers with those containing a low PPG grafting density (l-PGP−POEM). Furthermore, the gas separation performance of the membranes is systematically investigated as a function of POEM content in the comb copolymer. Both the permeance and selectivity of the PGP−POEM membranes are enhanced simultaneously with increase in the POEM content up to 51.2 wt % (PGP−POEM13), at which the best performance was achieved among the membranes. The high performance results from the reduced diffusion of N 2 due to the self-cross-linked structure as well as the increased CO 2 solubility due to the high content of ether oxygen groups in the comb copolymer. By optimizing the membrane thickness, the performance is further improved up to a CO 2 permeance of 500 GPU (1 GPU = 10 −6 cm 3 (STP)/(s cm 2 cmHg)) and CO 2 /N 2 selectivity of 22.4, which is close to the commercialization target area of CO 2 capture membranes. This work suggests a simple and economical crosslinking method to fabricate the membranes with excellent gas separation performance.

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