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Highly functionalized gamma-lactams are key intermediates for the synthesis of numerous biologically significant natural products. We herein described the synthesis of various chiral gamma-lactams via intramolecular C-H insertion of alpha-diazo-alpha-(phenylsulfonyl)acetamides derived from alpha-amino acids, which possess various functional groups. The cyclizations were highly regio- and stereoselective to afford chiral gamma-lactam motifs in high yields.

Highly Efficient Synthesis of Methyl-Substituted Conjugate Cyclohexenones.-The base-catalyzed annulation reaction of β-keto esters with conjugate enones or enals provides an efficient and mild method for the preparation of various alkyl substituted cyclohexenones, useful building blocks for the synthesis of natural products. -(CHONG, B.-D.; JI, Y.-I.; OH, S.-S.; YANG, J.-D.; BAIK, W.; KOO, S.; J.

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