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We report the large effort that is producing comprehensive high-level young star cluster (YSC) catalogs for a significant fraction of galaxies observed with the Legacy ExtraGalactic UV Survey (LEGUS) Hubble treasury program. We present the methodology developed to extract cluster positions, verify their genuine nature, produce multiband photometry (from NUV to NIR), and derive their physical properties via spectral energy distribution fitting analyses. We use the nearby spiral galaxy NGC 628 as a test case for demonstrating the impact that LEGUS will have on our understanding of the formation and evolution of YSCs and compact stellar associations within their host galaxy. Our analysis of the cluster luminosity function from the UV to the NIR finds a steepening at the bright end and at all wavelengths suggesting a dearth of luminous clusters. The cluster mass function of NGC 628The 1 is consistent with a power-law distribution of slopes~-2 and a truncation of a few times 10 5  M . After their formation, YSCs and compact associations follow different evolutionary paths. YSCs survive for a longer time frame, confirming their being potentially bound systems. Associations disappear on timescales comparable to hierarchically organized star-forming regions, suggesting that they are expanding systems. We find massindependent cluster disruption in the inner region of NGC 628, while in the outer part of the galaxy there is little or no disruption. We observe faster disruption rates for low mass (10 4  M ) clusters, suggesting that a massdependent component is necessary to fully describe the YSC disruption process in NGC 628.Astrophysical Journal, 841:131 (26pp), 2017 June 1 https:

The Legacy ExtraGalactic UV Survey (LEGUS) is a Cycle 21 Treasury program on the Hubble Space Telescope, aimed at the investigation of star formation and its relation with galactic environment in nearby galaxies, from the scales of individual stars to those of ∼kpc-size clustered structures. Five-band imaging, from the near-ultraviolet to the I-band, with the Wide Field Camera 3, plus parallel optical imaging with the Advanced Camera for Surveys, is being collected for selected pointings of 50 galaxies within the local 12 Mpc. The filters used for the observations with the Wide Field Camera 3 are: F275W(λ2,704Å), F336W(λ3,355Å), F438W(λ4,325Å), F555W(λ5,308Å), and F814W(λ8,024Å); the parallel observations with the Advanced Camera for Surveys use the filters: F435W(λ4,328Å), F606W(λ5,921Å), and F814W(λ8,057Å). The multi-band images are yielding accurate recent ( 50 Myr) star formation histories from resolved massive stars and the extinction-corrected ages and masses of star clusters and associations. The extensive inventories of massive stars and clustered systems will be used to investigate the spatial and temporal evolution of star formation * Einstein Fellow within galaxies. This will, in turn, inform theories of galaxy evolution and improve the understanding of the physical underpinning of the gas-star formation relation and the nature of star formation at high redshift. This paper describes the survey, its goals and observational strategy, and the initial science results. Because LEGUS will provide a reference survey and a foundation for future observations with JWST and with ALMA, a large number of data products are planned for delivery to the community.

A robust gonadotropin-releasing hormone (GnRH) surge is a prerequisite signal for the luteinizing hormone (LH) surge that triggers ovulation. In rodents, the GnRH surge is initiated by elevated estradiol and a diurnal switch in estrogen action from negative to positive feedback. The ability of constant estradiol treatment to induce daily LH surges was tested in adult mice that were ovariectomized (OVX) or OVX and treated with estradiol implants (OVX؉E). LH in OVX mice showed no time-of-day difference. In contrast, OVX؉E mice showed a large LH surge (8-to 124-fold relative to the a.m.) in p.m. samples on d 2-5 post-OVX؉E. Targeted extracellular recordings were used to examine changes in firing activity of GnRH neurons in brain slices. There was no time-of-day difference in cells from OVX mice. In contrast, OVX؉E cells recorded in the p.m. showed an increased mean firing rate and instantaneous firing frequency, which could increase GnRH release, and decreased duration of quiescence between bouts of firing, possibly reflecting increased pulse frequency, compared with cells recorded in the a.m. In the a.m., OVX؉E cells showed changes in GnRH neuron firing reflecting negative feedback compared with OVX cells, whereas in the p.m., OVX؉E cells exhibited changes suggesting positive feedback. These data indicate that differences in pattern and level of individual GnRH neuron firing may reflect the switch in estradiol action and underlie GnRH surge generation. The persistence of altered GnRH neuron activity in slices indicates that this approach can be used to study the neurobiological mechanisms of surge generation.luteinizing hormone ͉ mouse model ͉ surge ͉ electrophysiology ͉ neuroendocrinology

The nearby dwarf starburst galaxy NGC 5253 hosts a number of young, massive star clusters, the two youngest of which are centrally concentrated and surrounded by thermal radio emission (the "radio nebula"). To investigate the role of these clusters in the starburst energetics, we combine new and archival Hubble Space Telescope images of NGC 5253 with wavelength coverage from 1500 Å to 1.9 μm in 13 filters. These include Hα, Pβ, and Pα, and the imaging from the Hubble Treasury Program LEGUS (Legacy Extragalactic UV Survey). The extraordinarily wellsampled spectral energy distributions enable modeling with unprecedented accuracy the ages, masses, and extinctions of the nine optically brightest clusters (M V < −8.8) and the two young radio nebula clusters. The clusters have ages ∼1-15 Myr and masses ∼1 × 10 4 -2.5 × 10 5 M e . The clusters' spatial location and ages indicate that star formation has become more concentrated toward the radio nebula over the last ∼15 Myr. The most massive cluster is in the radio nebula; with a mass ∼2.5 × 10 5 M e and an age ∼1 Myr, it is 2-4 times less massive and younger than previously estimated. It is within a dust cloud with A V ∼ 50 mag, and shows a clear near-IR excess, likely from hot dust. The second radio nebula cluster is also ∼1 Myr old, confirming the extreme youth of the starburst region. These two clusters account for about half of the ionizing photon rate in the radio nebula, and will eventually supply about 2/3 of the mechanical energy in present-day shocks. Additional sources are required to supply the remaining ionizing radiation, and may include very massive stars.