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Following the conference 'Advanced Design Problems in Aerospace Engineering', which took place at the Ettore Majorana Centre for Scientific Culture (EMCSC) in Erice, Italy, this issue is presented by the Delft University of Technology, The Netherlands. Subject of the contribution of Delft Aerospace to this conference is the impact of new materials in future aeronautical vehicles.This special issue consists of five interrelated articles, Parts I to V. Each article deals with the potential of multi-disciplinary design. The first article introduces the multi-disciplinary design philosophy. The subsequent articles give examples of the potential that new materials, like fibre reinforced plastics, can offer to improve the design of a product (in our case an aircraft).Part II discusses two simple design problems: A tension loaded plate with stress concentrations and buckling of a composite plate.Part III to V focus on the integration of the acoustical insulation in an aircraft fuselage structure. Part III discusses the integration of acoustics and mechanics in a stiffened shell fuselage and Part IV in a sandwich fuselage. Part V deals with the application of a visco-elastic layer to improve the acoustical insulation of a stiffened shell fuselage.In the articles is focused on the integration of only the two design aspects, acoustics and mechanics. The goal of future research will be the integration of as many design aspects as possible into the fuselage structure.