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The fact theat all ordinary Illeal induces (definite Two criteria were used for differentiation bet\-een a normal and abnormal response of the electrocardiogram to a meal: the response wras considered to be abnormal (1) when, according to accepted standards,14 it was normal or borderline before the meal but abnormal after the meal;(2) when the changes exceeded the expectancy range for 98 per cent of the normal population.13In normal subjects it was found that the changes of CF4 or V4 were very similar,"3 so that the normal standards for V4 may also be applied for CF4.Patients. All patients were ambulatory and in a state of apparent compensation at the time of the test. Most of them were between 40 and 60 years of age. About half of the patients (45) were members of a large experimental group of 500 subjects presently under study of this Laboratory l5 In 29 patients, the electrocardiograms were the only abnormal (or borderline) findings of a thorough physiologic and clinical examination. Thus, the majority of our patients were in an incipient phase of cardiovascular degeneration, except a group of 23 patients with diagnosed corona'y insufficiency,.The patients were grouped into six major categories: (I) Suspected coronary insufficiency (16 pa-

The object of the study was to investigate the effect on gonadotrophin secretion of a small increase in oestradiol concentration. A total of 13 fully breast-feeding women (12 weeks post-partum) underwent serial blood sampling at 10 min intervals for 12 h on 2 different days; day 1 untreated and day 5 after 3 days of treatment with transcutaneous oestradiol (100 micrograms/day). On both days bolus gonadotrophin-releasing hormone (GnRH; 10 micrograms i.v.) was given after a 10 h baseline period. In six of the subjects, a naloxone infusion was administered during the second study day. Application of transdermal oestradiol raised the oestradiol concentration within the normal follicular phase range. The mean luteinizing hormone (LH) concentration on day 5 was found to be significantly lower than that on day 1 (P < 0.05). The LH response to GnRH was, however, significantly higher on day 5 than day 1 (P < 0.001). The mean follicle stimulating hormone (FSH) concentration on day 5 was also significantly lower than that on day 1 (P < 0.01), while the peak concentration after GnRH was unchanged. When the opioid antagonist naloxone was infused after oestradiol treatment, the subjects with low pre-study oestradiol concentrations exhibited no effect on LH concentration, while in the subjects with higher oestradiol concentrations the LH concentration was increased. It was concluded that the administration of small doses of oestradiol caused a significant fall in gonadotrophin concentration in breast-feeding women.(ABSTRACT TRUNCATED AT 250 WORDS)

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