Increased CSD in DS, correlating with cognitive performance, for both slow and fast rhythms suggests involving of cortical and subcortical mechanisms. LORETA might be useful for objective measure of cognitive decline in DS.

Anosognosia for cortical blindness, also called Anton’s syndrome, is a rare neurological disorder usually following bilateral lesions to occipital cortices. Neuropsychological, morphological and functional neuroimaging (SPECT and fMRI) findings are reported in a patient who incurred Anton’s syndrome after an ischaemic lesion confined to the left occipital lobe involving the corpus callosum. The present case study suggests that Anton's syndrome may also follow from lesions disconnecting the occipital cortices.