CNS Melioidosis is a rare and complicated form of Melioidosis with a mortality rate of up to 50%. We hereby present a case of CNS Melioidosis with bacteremia and pulmonary manifestations of Melioidosis based on CT Chest imaging ndings, who on prompt initiation of appropriate IV antibiotic therapy along with craniotomy and drainage of cerebral abscess showed drastic recovery. This indolent multi systemic presentation along with the rarity of CNS Melioidosis in general, makes this case report note-worthy.