Interaction between surfactants forms micelles that typically lead to a reduction of the irritation potential of the mixture. The objective of this study is to illustrate that such antagonism between surfactants is applicable to actual cases of consumer products e.g. laundry detergent products. The Zein test is an in vitro assay measuring corn protein denaturation by solutions of surfactant(s) and often used to predict their acute irritation potential. The Zein test data for the surfactant mixtures from nine representative laundry detergents demonstrate that the protein denaturation by the mixtures is, in all cases, lower than the cumulative score of protein denaturation by the different surfactants tested separately. The data clearly indicate that antagonism occurs between the actual surfactants present in their exact proportions as found in the consumer laundry detergent products. These data support the view that the hazard classification of detergent products as (irritant) by the dangerous preparation directive should not be based on a simple cumulative score of the irritation properties of the individual components of the products.