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Aim of the work: To follow the efficiency of the Sertraline (Asentra) treatment in patients with anxiety and depression symptoms after cardio-surgical interventions. Materials and methods: During the research we included 30 patients with anxiety and depression symptoms after cardio-surgical intervention. They were chosen randomly, hospitalized and treated in the Specialized cardio-surgical clinic Filip II, Skopje. The patients were of both sexes, aged 30-65. They were all treated with Asentra tablets in dosages of 50mg taken only in the morning over the period of 3 months. They were evaluated by HAMD and HAS in the beginning, after being treated for 4 weeks and after being treated for 6 months. Results: In 18 patients there was a significant improvement which resulted in score decline. In 5 patients there was a slight improvement. And in 7 patients there was no significant improvement after 4 weeks or after 6 months. Conclusion: Asentra(Sertraline) efficient and safe SSRI antidepressive in treating patients with anxiety and depression symptoms after cardio-surgical interventions.