Glycoproteins gp5O, gll, and glll of pseudorabies virus (PRV) were expressed either individually or in combination by vaccinia virus recombinants. In vitro analysis by immunoprecipitation and immunofluorescence demonstrated the expression of a gll protein of approximately 120 kDa that was proteolytically processed to the glIb (67to 74-kDa) and glIc (58-kDa) mature protein species similar to those observed in PRV-infected cells. Additionally, the proper expression of the 90-kDa gIll and 50-kDa gp5O was observed. All three of these PRVderived glycoproteins were detectable on the surface of vaccinia virus-PRV recombinant-infected cells. In vivo, mice were protected against a virulent PRV challenge after immunization with the PRV glycoprotein-expressing vaccinia virus recombinants. The coexpression of gll and glll by a single vaccinia virus recombinant resulted in a significantly reduced vaccination dose required to protect mice against PRV challenge. Inoculation of piglets with the various vaccinia virus-PRV glycoprotein recombinants also resulted in protection against virulent PRV challenge as measured by weight gain. The simultaneous expression of gll and gpSO in swine resulted in a significantly enhanced level of protection as evaluated by weight evolution following challenge with live PRV.

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The purpose of this paper is to take stock of the knowledge gained over the last few years on Feline Infectious Peritonitis in a synthetic way.Apart from the bibliographical study regarding the works of numerous authors, we state our results concerning the study of the experimental reproduction of the disease.From all the cat infectious diseases, Feline Infectious Peritonitis is the clinical entity the most recently evidenced. In this paper we shall state the elements now clearly established on this disease but numerous points are still to be made clear. Contagious disease of viral origin, it affects domestic and wild Felidae. Clinically, in its most typical form, it is characterised by the progressive development of an exudative sero-fibrinous peritonitis and a febrile and gradual weakness of the general condition. It slowly and regularly develops into death,

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