African American (AA) women have a lower overall incidence of breast cancer than do Caucasian (CAU) women, but a higher overall mortality. Little is known as to why the incidence of breast cancer is lower yet mortality is higher in AA women. Many studies speculate that this is only a socio-economical problem. This investigation suggests the possibility that molecular mechanisms contribute to the increased mortality of AA women with breast cancer. This study investigates the expression of 14 genes which have been shown to play a role in cancer metastasis. Cell lines derived from AA and CAU patients were analyzed to demonstrate alterations in the transcription of genes known to be involved in cancer and the metastatic process. Total RNA was isolated from cell lines and analyzed by RT-PCR analysis. Differential expression of the 14 targeted genes between a spectrum model (6 breast cancer cell lines and 2 non-cancer breast cell lines) and a metastasis model (12 metastatic breast cancer cell lines) were demonstrated. Additionally, an in vitro comparison of the expression established differences in 5 of the 14 biomarker genes between African American and Caucasian breast cell lines. Results from this study indicates that altered expression of the genes Atp1b1, CARD 10, KLF4, Spint2, and Acly may play a role in the aggressive phenotype seen in breast cancer in African American women.

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tribution quotients for strontium. Dsr, and barium, DBa, were calculated for stages throughout the extractor. I n the scrub section, Ds, had values in the range of 0.7 to 1.1. while DBs had values, except for stage 3, in the range of 0.2 to 0.3.The separation factors, p values, for the scrub section were in

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A new, extremely sensitive method for the quantitative determination of tellurium is based on the induced precipitation of elemental gold from a 6N HCl solution containing gold chloride, cupric chloride, and hypophosphorous acid; the amount of gold reduced is proportional to the amount of tellurium present. As little as 1 nanogram (1 X 1O(-9) g) of tellurium gives a measurable reaction with 1 mg of gold in 50 ml of solution.