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Aim: To review the literature on the oral health status of the population, evidence-based understanding of epigenetic mechanisms, and its significant role in diseases occurring in the oral cavity. Background: Epigenetics is the study of heritable changes in gene expression that does not involve changes to the underlying DNA sequence. In other words, it is a change in phenotype without a change in genotype, which in turn affects the way cells read genes. Epigenetic change is a regular and natural occurrence but can also be influenced by several factors including age, the environment/lifestyle, and disease state. The field of epigenetics is quickly growing, and it is believed that both the environment and lifestyle can interact with the genome to influence epigenetic change. These changes may be reflected at various stages throughout a person's life and even in later generations. Conclusion: Epigenetic codes help us understand the biological phenotype that arises from the interaction of the human genome with the environment in health and in disease. Epigenetics is a major turn away from molecular biology. Current epigenetics not only offers new insights into gene regulation and heredity, but also it challenges the way we think about evolution, genetics, and development. Most interestingly, it suggests testable mechanisms whereby environmental factors (ranging from stress to infection) can influence genetic expression.

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L-prolinamide, 5-oxo-l-prolyl-l-phenylanyl-4-hydroxy(5.19%). Antifungal activity of the ethyl acetate extract of the secondary metabolites were examined against Pythium spp MTCC 10247 and result revealed that the lag period of the fungi was double fold higher than the control and the compounds were fungi static because there was a 57% of growth reduction after 7 th day of incubation period. All the seven compounds were used for molecular docking study and result showed higher score value with L-prolinamide, 5-oxo-l-prolyl-lphenylanyl-4-hydroxy

The present work was undertaken using a seaweed liquid fertilizer extracted from the red algae Coralline mediterranea. The study plant chosen was Abelmoschus esculentus because we had already used the same plant to study the effects of Kappaphycus alverazii and we have found out amazing results. Seaweed liquid fertilizer extracted from the red algae Coralline mediterranea were having many biologically active compounds like glycosides, flavonoids, anthraquinone, resin and tannins. Antimicrobial activity of ethanolic root extract of the study plant was carried out which showed moderate sensitivity against E.coli but the control plant root extract was resistant to E. coli. GCMS result of ethanol extract of control plant had some exclusive compounds.They were phenol -2-(1-phenyl ethyl), 1,2-Benzene dicarboxylic acid, bis(2-methyl propyl)ester, hexadeconic acid methyl ester, methyl octadec -9-enoate, stearic acid methyl ester, linear isopropyl phenol dimer, 9-ocatadienolic acid, methyl ester and diisooctyl phthalate. Untreated but the plants closer to the vicinity of the treated plants had some exclusive compounds. They were 1,3,4-oxadiazol-2-amine,5-phenyl, 1,6-dimethyl(1,2,4)triazole(3,4-c) (1,24) triazin-5(1H)-one, acetone,N2-(4-hydroxy-6-methyl pyrimidine-2-yl)hydrazine, 2-methoxyethyl semithiocarbaxide and 2H-Imidazole-2-thione,1,3-dihydr. All these compounds were absent in the treated plant root extract but it had phenol, 2-amino-4-(1H-1,2,3,4 tetrazole) 1-yl and Hydrazine -2-imidazole as an exclusive compounds. Though the peak compounds for both treated plants and the plants in the adjacent lane of treated were same but amount of 13-Heptadecyn-1-ol was 88.15% in treated