T he article describes the new proprietary spot-on TM technology developed by Allegro Technologies, Ltd., for nanolitre and microlitre dispensing of liquids for the drug discovery, genomics and proteomics industries. We analyze the requirements of the drug discovery industry for low volume liquid handling technologies and briefly summarize some the more common technologies currently available.A detailed description is provided of the new spot-on TM technology in terms of function and operation as well as the relevant features and potential benefits to using this new method of nanolitre dispensing.