Introduction The treatment of haemophilia varies across countries and across regions within some countries. Similar variation has been observed in health‐related quality of life (HR‐QoL). Relatively little is known about the HR‐QoL of boys with haemophilia in China. Aim The aim of this study was to describe the HR‐QoL of boys with haemophilia in China using the Canadian Haemophilia Outcomes‐Kids Life Assessment Tool (CHO‐KLAT). Methods Boys (4‐18 years of age) with haemophilia and their parents were enroled in a cross‐sectional study. All parents/guardians of study subjects were requested to complete a CHO‐KLAT questionnaire during a clinic visit, and report on several other clinical and socioeconomic factors in the past year. Boys who were > 7 years also completed the CHO‐KLAT. Results A total of 269 parents of boys with haemophilia, from 13 hospitals in 12 provinces, were enroled during 2014. The boys ranged from 4.0 to 17.9 years of age; 91% had haemophilia A, most had moderate (52%) or severe (36%) disease, and most were receiving sub‐optimal on‐demand therapy or low‐dose prophylactic therapy. Child self‐report CHO‐KLAT scores were available for 171 boys ≥7 years of age and ranged from 24.2 to 85.3 with a mean of 57.6 (n = 171). Parent proxy‐reported CHO‐KLAT scores ranged from 25.0 to 88.7 with a mean of 55.1 (n = 269). Conclusion HR‐QoL scores in boys with haemophilia in China were substantially lower than reported from Canadian and European boys with haemophilia. Longer term prospective studies are required to examine the factors impacting the HR‐QoL for boys with haemophilia in China.