Decision making in immuno-oncology is pivotal to adapt therapy to the tumor microenvironment (TME) of the patient among the numerous options of monoclonal antibodies or small molecules. Predicting the best combinatorial regimen remains an unmet medical need. Here, we report a multiplex functional and dynamic immuno-assay based on the capacity of the TME to respond to ex vivo stimulation with twelve immunomodulators including immune checkpoint inhibitors (ICI) in 43 human primary tumors. This "in sitro" (in situ/in vitro) assay has the potential to predict unresponsiveness to anti-PD-1 mAbs, and to detect the most appropriate and personalized combinatorial regimen. Prospective clinical trials are awaited to validate this in sitro assay.

Abstract. Fifteen total hip replace-

Forniceal rupture secondary to acute ureteral obstruction is relatively common. However, spontaneous ureteral rupture is less frequently encountered. Most reported cases were stone related, localized at the ureteropelvic junction and managed in a minimally invasive manner. We present a case of stone induced ureteral rupture below the UPJ, with bacterial and fungal superinfections, that failed conservative management and lead eventually to nephrectomy. No such scenario has ever been reported in the literature. As rupture of the ureter can cause serious complications, including urinoma, sepsis and sometimes kidney loss, prompt recognition, treatment and follow-up of the condition is therefore necessary.

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