In this paper, the load distribution of a bolt connection structure with a variable thread profile at high temperature is investigated. The parameters of time-hardening creep model of aluminum alloy at high temperature were obtained by fitting the uniaxial creep tensile test data of aluminum alloy at 250 • C. Based on ABAQUS, a two-dimensional axisymmetric model of the bolt connection structure was established, and according to the thread load distribution considering linear elasticity, plasticity and creep characteristics, modification of standard metric thread profile was carried out. The load distribution law of the thread of the modified bolt connection structure were investigted. The results show that the load--bearing ratio of the first thread can be significantly reduced and the load-bearing distribution uniformity of all threads can be improved when the modified thread is applied to the bolt connection structure.